Immunogenic Peptides

 

Not conserved between homologous proteines e.g. isoenzymes from different species !

 

 

B-Zell-Epitope

 

Structure:                  

                           -       length >= 10 AS

                           -       surface position of Aa in protein

                                   use programs such as e.g.  PEPTIDESTRUCTURE / GCG

                                   use moving 6(7) Aa - window

                           -       high Aa-Sequence variability

                           -       hydrophilic

                           -       secondary structure